Prof. Jen Gommerman

Fellow of the College
Associate Professor, Dept. of Immunology, U of T
Department of Immunology, Medical Sciences Building, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8
Fax: 416-978-1938

BSc (Immunology), University of Toronto, 1993

PhD (Immunology), University of Toronto, 1998

Teaching Area:

Research Interests:
Immunology and autoimmunity

Selected Peer-reviewed Publications:

1. Satpathy A.T., Briseo C.G., Lee J.S., Ng D., Manieri N.A., Kc W., Wu X., Thomas S.R., Lee W.L,, Turkoz M., McDonald K.G., Meredith M.M., Song C., Guidos C.J., Newberry R.D., Ouyang W., Murphy T.L., Stappenbeck T.S., Gommerman J.L., Nussenzweig M.C., Colonna M., Kopan R., Murphy K.M. Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens. Nat Immunol. 2013 Sep;14(9):937-48
2. Ng, D. and Gommerman, J.L. The regulation of immune responses by DC derived Type I IFN. Front. Immunol. 4:94, 2013.
3. Galicia, G., Boulianne, B., Pikor, N., Martin, A. Gommerman, J.L. Secondary B cell Receptor diversification is necessary for T cell mediated neuro-inflammation during Experimental Autoimmune Encephalomyelitis. PlosOne 8:e61478, 2013.
4. Galicia-Rosas, G., Pikor, N., Schwartz, J.A., Rojas, O., Jian, A., Summers-Deluca, L., Ostrowski, M., Nuesslein-Hildesheim, B. Gommerman, J.L. A Sphingosine-phosphate Recdeptr 1-directed agonist reduces Central Nervous System Inflammation in a Plasmacytoid Dendritic Cell-dependent manner. J. Immunol. 189:3700, 2012
5. Kim CJ, Nazli A, Rojas OL, Chege D, Alidina Z, Huibner S, Mujib S, Benko E, Kovacs C, Shin LY, Grin A, Kandel G, Loutfy M, Ostrowski M, Gommerman JL, Kaushic C, Kaul R. A role for mucosal IL-22 production and Th22 cells in HIV-associated mucosal immunopathogenesis. Mucosal Immunol. 2012 Aug 1. doi: 10.1038/mi.2012.72. [Epub ahead of print]
6. Fritz, J.H., Lucia-Rojas, O., Simard, N., McCarthy, D., Hapfelmeier, S., Rubino, S., Robertson, S.J., Larijani, M., Ivanov, I.I., Martin, A., Casellas, R., Philpott, D.J., E. Girardin, S., McCoy, K.D, Macpherson, A.J., Paige, C.J. and Gommerman, J.L. Acquisition of a multifunctional TNF/iNOS-producing IgA+ plasma cell phenotype in the gut. Nature, 481:199, 2012 (Highlighted in Nature Immunology).
7. Summers-Deluca, L. and Gommerman, J.L. Fine tuning of dendritic cell biology by the TNF superfamily. Nature Reviews Immunology, 12:339-351, 2012
8. McCarthy, D.D., Kujawa, J., McPherson, A.J., McCoy, K.D., Pei, Y., Ranger, A., Gommerman, J.L.* and Browning, J.L.*. Mice over-expressing BAFF develop a disease resembling human IgA Nephropathy that is dependent on commensal flora. J. Clinical Investigation, 121:3991, 2011
*J. Gommerman and T. Mak are co-corresponding authors having made equal contributions
9. Summers-Deluca, L., Ng, D., Gao, Y., Ward, L.E. and Gommerman, J.L. Dendritic cells integrate CD40 and LTβR-signals to optimize cross-priming of CD8+ T cell responses. PNAS 108:2046, 2011
10. Summers-Deluca, L. and Gommerman, J.L. LTBR and CD40: working together in DC to optimize immune responses. Immunological Reviews. 244:85-98, 2011.
11. Summers-Deluca, L., Pikor, N., O’Leary, J., Galicia-Rosas, G., Ward, L.E., Osborne, L.R. and Gommerman, J.L. Sub-strain differences are the major source of variability in a rodent model of Multiple Sclerosis. J. Immunol. 184:3174, 2010
12. Tusche, M., Ward, L.E., Vu, F., McCarthy, D., Gommerman, J.L. * and Mak, T.W. Differential requirement of MALT1 for BAFF-induced outcomes in B cell subsets. J. Exp. Med. 206:2671, 2009
*J. Gommerman and T. Mak are co-corresponding authors having made equal contributions.
13. Gao, Y., Majchrzak, B., Fish, E.N., and Gommerman, J.L. Dynamic accumulation of plasmacytoid dendritic cells in lymph nodes is regulated by type I Interferon-beta. Blood 114:2623, 2009
14. Zaheen, A.*, Boulianne, B.*, Ramachandran, S., Parsa, J-Y., Gommerman, J.L.* and Martin, A.* AID constrains Germinal Center size by Rendering B cells Susceptible to Apoptosis. Blood 114:547, 2009
*J. Gommerman and A. Martin are co-corresponding authors having made equal contributions.
15. Gamelas Magalhaes*, J.H. Fritz*, Le Bourhis, L., Sellge, G., Travassos, L.H., Selvanantham, T., Girardin, S., Gommerman, J.L., Philpott, D.J. Nod2-dependent Th2 polarization of antigen-specific immunity. J. Immunol. 181:7925, 2008
16. Vu, F., Dianzani, U., Ware, C.F., Mak, T. and Gommerman, J.L. ICOS, CD40 and Lymphotoxin-beta Receptors signal sequentially and inter-dependently to initiate a Germinal Center reaction. J. Immunol. 180:2284, 2008.
17. Summers-Deluca, L., Cosovic, B., McCarthy, D.D., Scheu, S., Pfeffer, K. and Gommerman, J.L. Expression of Lymphotoxin-ab on antigen-specific T cells is required to license dendritic cells in vivo. J. Exp. Med. 204:1071, 2007
18. McCarthy, D.D*, Gao, Y-F, Chiu, S., Summers-Deluca, L. and Gommerman, J.L. LIGHT is dispensable for BAFF-mediated hyper-IgA syndrome. Cell. Immunol. 241:85, 2006

Awards, Affiliations, Personal Interests, etc.:
Honours and Awards:

2008 ISICR Research Travel Award
2006 American Society of Immunologists Jr Faculty Travel Award
2004 Canadian Society of Immunologists Jr Faculty Travel Award
2004 – 2009. CIHR New Investigator Salary Award
1999 American Association of Immunologists Trainee Award
1998 – 2001. Medical Research Council Post-Doctoral Fellowship
1997 Hardi Cinnader Prize in Immunology
1997 Canadian Society for Immunology Travel Award
1995 American Association for Cancer Research Travel Award
1994 – 1998. Connaught Life Sciences Scholarship


1999 – present Member of the American Association of Immunologists
2007 – present Member of the Canadian Association of Gastroenterology
1997 – present Member of the Canadian Society for Immunology

Personal Interests:

Camping, Canoeing, Cycling, Golden age of Detective Fiction, Gilbert and Sullivan

Jen Gommerman